Sheryl T. Smith

Sheryl T. Smith

Assistant Professor of Biology
smiths@arcadia.edu

Dr. Sheryl Smith received her B.S. in Biology and B.S. in Psychology from King's College in 1988, an M.A. in Biochemistry from The University of Scranton in 1993 and a Ph.D. in Developmental Biology and Teratology from Thomas Jefferson University in 2003. Her postdoctoral training was completed at the Wistar Institute in Philadelphia, Pa., before joining the Biology faculty at Arcadia University in 2007. Dr. Smith’s research interests include gene regulation during development and improper regulation of genes leading to birth defects. She uses Drosophila melanogaster (fruit fly) as a model system to study a cluster of genes that is highly conserved throughout evolution, and is responsible for specifying proper body structures in the correct order along the anterior-posterior axis of the organism.

Research Interests

Dr. Smith’s research interests include non-coding DNA Insulator sequences that have defined functions in genome organization, regulation of enhancer-promoter communication and in barrier activity to prevent the spread of repressive chromatin. Dr. Smith and colleagues have recently conducted a genome-wide analysis of sequences that bind to the protein CTCF in Drosophila melanogaster. They discovered a specific class of CTCF-associated insulator sequences that are biased toward genes and therefore may play a more direct role in transcription regulation. Her current work is focused on the evolution of CTCF-associated insulator sequences in contributing to phenotypic diversity among species.

Dr. Smith’s lab is also interested in the effects of environmental toxicants, such as Bisphenol-A (BPA), PFOA, DHEP and BHA on development. Her group has recently shown that the environmental toxicant, BPA, affects growth and metamorphosis in Drosophila.

Recent Publications

  • Smith ST, Wickramasinghe P, Olson A, Loukinov D, Lin L, Deng J, Xiong Y, Rux J, Sachidanandam R, Sun H, Lobanenkov V, Zhou J. , Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization. Dev Biol. 2009 Apr 15;328(2):518-28.
  • Petruk, S.,  Smith ST, Sedkov, Y., and Mazo A. (2008) Association of trx-G and PcG with proteins of the bxd maintenance element depends on transcriptional activity. Development Jul; 135 (14) 2383-90.
  • Chen, Q., Lin, L, Smith, ST., Lin Q., Zhou J (2005). "Multiple Promoter Targeting Sequences exist in Abdominal-B to regulate long-range gene activation." Developmental Biology 286: 629-636 Link
  • Moon H, Filippova G, Loukinov D, Pugacheva E, Chen Q, Smith ST, Munhall A, Grewe B, Bartkuhn M, Arnold R, Burke LJ, Renkawitz-Pohl R, Ohlsson R, Zhou J, Renkawitz R, Lobanenkov V. (2005). "CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator." EMBO Rep 6(2):165-70 Link
  • Smith, S.T., Sedkov, Y., Petruk, S., Cho, E., Tillib, S., Canaani, E., Mazo, A. (2004). "Modulation of the Heat Shock Response in Drosophila by the Chromatin Modifying Complex, TAC1." Nature Cell Biology 6(2):162-167 Link
  • Sedkov, Y., Cho-Fertikh, E., Petruk, S., Smith, S., Cherbas, L., Cherbas, P., Jones, R.S., Canaani, E., Jaynes, J.B., and Mazo, A., (2003)."Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila." Nature. 426: 78-83 Link
  • Petruk S, Sedkov Y, Smith S, Tillib S, Kraevski V, Nakamura T, Canaani E, Croce CM, Mazo A. (2001). "Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene." Science. 294 (5545):1331-4 Link

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